CAST
Aaron Stanford as Doug Bukowski
Kathleen Quinlan as Ethel Carter
Vinessa Shaw as Lynn Carter-Bukowski
Emilie de Ravin as Brenda Carter
Dan Byrd as Bobby Carter
Tom Bower as Gas Station Attendant
Billy Drago as Papa Jupiter
Robert Joy as Lizard
Ted Levine as Big Bob Carter
Desmond Askew as Big Brain
Ezra Buzzington as Goggle
Michael Bailey Smith as Pluto
Laura Ortiz as Ruby
Maisie Camilleri Preziosi as Catherine Bukowski
Gregory Nicotero as Cyst
PLOT
Retired detective Bob Carter and his wife Ethel are travelling from Cleveland to San Diego through the New Mexico desert for their silver wedding anniversary; with them are their three children, Lynn, Brenda, and Bobby, Lynn's husband Doug and their baby daughter Catherine, and their two German Shepherds, Beauty and Beast. They stop at a gasoline station where the elderly attendant suggests a different route through the hills, claiming it'll save them a few hours. shortly after, their tires are punctured by a hidden spike strip, causing the truck and trailer to crash.
Bob and Doug depart in opposite directions to find help while the rest of the family stay by the trailer. Beauty escapes and, when Bobby chases her into the hills, he finds her mutilated corpse. Horrified, he flees back to the trailer but falls off Capitol Hill on the way, knocking himself unconscious. A timid female mutant Ruby protects him from her brother Goggle. Meanwhile, Bob arrives back at the gasoline station . Upon searching the station, he finds newspaper clippings detailing various disappearances within the area after recent nuclear testings at a mining town by the US government that caused the mutants' deformities. He confronts the attendant who then shoots himself. Bob attempts to escape in an abandoned car but is attacked by the mutant leader Papa Jupiter.Bobby is found by Brenda, but he decides to not tell his family about Beauty. Doug returns after heading towards the interstate and finding nothing but an enormous crater filled with numerous cars and other belongings. Worried that his father has not come , Bobby tells Doug and Lynn he doesn't think they're alone within the desert, even as Pluto and Lizard infiltrate the trailer. They attack and rape Brenda, who has stayed within the trailer with Catherine, while employing a distraction of immolating Bob to a tree to divert the others. When Lynn and Ethel return to the trailer, Lizard shoots both of them before abducting Catherine, then escapes with Pluto. Doug and Bobby return to get the carnage; Lynn and Ethel die shortly afterwards.
The next morning, Doug, together with Beast, began to rescue Catherine. He comes across an abandoned nuclear testing village through the miner town's cave system but is knocked unconscious by Big Mama. Awakening in an ice box, he escapes and encounters Big Brain who reveals the mutants' origins to him. Pluto appears and attacks Doug but he manages to realize the upper hand and kills Pluto with his own axe before killing another mutant, Cyst. After ordering Lizard to kill Catherine, Big Brain is mauled to death by Beast. Ruby manages to require the baby from Lizard and escapes through the hills.
Back at the trailer, Brenda and Bobby build an explosive trap, which they depart when Brenda is attacked by Jupiter. Meanwhile, Doug catches up with Ruby but Lizard attacks them before Ruby can hand Catherine over. A struggle ensues and Doug manages to defeat him with Cyst's shotgun. Ruby then gives Doug his daughter back. Lizard, still alive, aims the shotgun at Doug but Ruby tackles Lizard off a cliff, sending them both falling to their deaths.
Bobby and Brenda find Jupiter wounded from their trap and Brenda finishes him off with a pickaxe before the siblings are reunited with Doug, Catherine, and Beast. because the survivors of the Carter family embrace, an unknown mutant watches them from afar through binoculars.
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